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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ervin G N, Nemeroff C B

Molecular Pharmacology Department, Glaxo Inc., Research Triangle Park, North Carolina.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12 Suppl:S53-69. doi: 10.1016/0278-5846(88)90073-5.

Neurotensin (NT) is a tridecapeptide that fulfills many of the requisite criteria for neurotransmitter status in the mammalian central nervous system. 2. Neuroanatomical studies have revealed that DA and NT neurons are proximal in several limbic areas and that NT receptors are present on both DA perikarya and certain DA nerve terminals. 3. When injected intraventricularly or directly into the nucleus accumbens (ACC), NT produces effects similar to antipsychotic drugs, e.g. blockade of the hyperactivity produced by d-amphetamine or cocaine. 4. Chronic administration of antipsychotic drugs such as haloperidol produces increases in NT concentration in the ACC and caudate nucleus. Atypical antipsychotic drugs produce increases in NT concentration only in the ACC. 5. In certain drug-free schizophrenic patients, the concentration of NT in cerebrospinal fluid is reduced. 6. It appears that NT may modulate the activity of DA neurons in the mesolimbicocortical DA system.

神经降压素（NT）是一种十三肽，满足哺乳动物中枢神经系统中神经递质状态的许多必要标准。2. 神经解剖学研究表明，多巴胺（DA）和神经降压素神经元在几个边缘区域相邻，并且神经降压素受体存在于多巴胺胞体和某些多巴胺神经末梢上。3. 当脑室内注射或直接注射到伏隔核（ACC）时，神经降压素产生类似于抗精神病药物的作用，例如阻断由右旋苯丙胺或可卡因引起的多动。4. 长期施用抗精神病药物如氟哌啶醇会导致伏隔核和尾状核中神经降压素浓度增加。非典型抗精神病药物仅使伏隔核中的神经降压素浓度增加。5. 在某些未服用药物的精神分裂症患者中，脑脊液中神经降压素的浓度降低。6. 似乎神经降压素可能调节中脑边缘皮质多巴胺系统中多巴胺神经元的活动。

Ervin G N, Nemeroff C B

Molecular Pharmacology Department, Glaxo Inc., Research Triangle Park, North Carolina.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12 Suppl:S53-69. doi: 10.1016/0278-5846(88)90073-5.

Neurotensin (NT) is a tridecapeptide that fulfills many of the requisite criteria for neurotransmitter status in the mammalian central nervous system. 2. Neuroanatomical studies have revealed that DA and NT neurons are proximal in several limbic areas and that NT receptors are present on both DA perikarya and certain DA nerve terminals. 3. When injected intraventricularly or directly into the nucleus accumbens (ACC), NT produces effects similar to antipsychotic drugs, e.g. blockade of the hyperactivity produced by d-amphetamine or cocaine. 4. Chronic administration of antipsychotic drugs such as haloperidol produces increases in NT concentration in the ACC and caudate nucleus. Atypical antipsychotic drugs produce increases in NT concentration only in the ACC. 5. In certain drug-free schizophrenic patients, the concentration of NT in cerebrospinal fluid is reduced. 6. It appears that NT may modulate the activity of DA neurons in the mesolimbicocortical DA system.

神经降压素（NT）是一种十三肽，满足哺乳动物中枢神经系统中神经递质状态的许多必要标准。2. 神经解剖学研究表明，多巴胺（DA）和神经降压素神经元在几个边缘区域相邻，并且神经降压素受体存在于多巴胺胞体和某些多巴胺神经末梢上。3. 当脑室内注射或直接注射到伏隔核（ACC）时，神经降压素产生类似于抗精神病药物的作用，例如阻断由右旋苯丙胺或可卡因引起的多动。4. 长期施用抗精神病药物如氟哌啶醇会导致伏隔核和尾状核中神经降压素浓度增加。非典型抗精神病药物仅使伏隔核中的神经降压素浓度增加。5. 在某些未服用药物的精神分裂症患者中，脑脊液中神经降压素的浓度降低。6. 似乎神经降压素可能调节中脑边缘皮质多巴胺系统中多巴胺神经元的活动。