Experiments on 10 right-handed subjects were carried out to study the topographic organization of cortical activation processes by means of toposcopy of synchronous electric activity in hypnotic analgesia. The authors demonstrate the priority role of the anterior cortical areas of the left hemisphere in analgesia effects, which is connected with their importance in data realization and formation of the motivation affective component of painful sensation. Experiments have shown different manifestations of the functioning of diffuse nonspecific and local specific activation processes maintaining sensory analysis of painful stimuli and their affective cognitive estimation in the systems responsible for individual tolerance to painful sensations and analgesia effects and demonstrated a possibility of observing at the level of objective electrophysiological parameters of the phenomenon of pain components dissociation as one of the mechanisms of hypnotic analgesia.