Haas A L
Department of Biochemistry, Medical College of Wisconsin, Milwaukee.
Adv Exp Med Biol. 1991;307:191-205. doi: 10.1007/978-1-4684-5985-2_18.
Response of the ATP, ubiquitin-dependent system during the enhanced degradation of erythrocyte maturation conforms to the general regulatory features common to several similar but unrelated systems. In erythroid cells enhanced degradation follows three phases: (1) Onset of degradation characterized by an increase in the intracellular concentration of free and conjugated ubiquitin, brought about by reduction in mean cell volume; (2) Active enhanced degradation during cellular remodeling; and (3) Loss of activity as a consequence of spontaneous inactivation of components required for ubiquitin conjugation. The extent of degradative remodeling is probably functionally limited by the loss of these critical ligation enzymes.
在红细胞成熟增强降解过程中，ATP依赖的泛素系统的反应符合几个相似但不相关系统共有的一般调节特征。在红系细胞中，增强降解遵循三个阶段：(1) 降解开始，其特征是平均细胞体积减小导致游离和结合泛素的细胞内浓度增加；(2) 细胞重塑期间的主动增强降解；(3) 由于泛素缀合所需成分的自发失活而导致活性丧失。降解重塑的程度可能在功能上受到这些关键连接酶丧失的限制。
