Leiva M C, Xu Q, Galman M, Lyttle C R
Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Biol Reprod. 1991 Dec;45(6):818-23. doi: 10.1095/biolreprod45.6.818.
The ontogeny of an estrogen-induced eosinophil chemotactic activity in the uterus after estrogen administration and its regulation by progesterone was studied in neonatal rats at 3, 7, 10, and 13 days of age. These results were compared with the increase in peroxidase activity and the secretion of complement component C3 by the uterus. No chemotactic activity was observed in animals younger than 14 days, and after this age the estrogen regulation of the response was also prevented by the co-administration of progesterone. The secretion of complement C3 appeared earlier, at 10 days of age. It was also observed that the uterus of 3-7-day-old rats responded to estrogen by increasing the secretion of two proteins of 36 and 110 kDa. No further regulation or synthesis was observed with increasing age for these two proteins.
在3、7、10和13日龄的新生大鼠中，研究了雌激素给药后子宫中雌激素诱导的嗜酸性粒细胞趋化活性的个体发生及其受孕酮的调节。将这些结果与子宫中过氧化物酶活性的增加和补体成分C3的分泌进行了比较。在14日龄以下的动物中未观察到趋化活性，在此年龄之后，孕酮的共同给药也阻止了雌激素对反应的调节。补体C3的分泌在10日龄时出现得更早。还观察到，3至7日龄大鼠的子宫通过增加36 kDa和110 kDa两种蛋白质的分泌来响应雌激素。随着年龄的增长，这两种蛋白质未观察到进一步的调节或合成。
