Dzodzikova M E, Shakhlamov V A, Berezov T T, Salbiev K D
Morfologiia. 2005;128(5):60-4.
Using the methods of light and electron microscopy, morphometric and functional characteristics of mast cell (MC) populations were studied in the mammary gland (MG) and regional lymph node (RLN) at different stages of breast cancer (BC) induced in 120 outbred female albino rats with the body mass of 120-150 g. BC was induced by subcutaneous injections of chemical cancerogen N-methyl-N-nitrosourea. MC numbers and activity in MG and RLN were found to increase at all stages of BC formation studied (64-180 days of cancerogen exposure). Gradual increase in MC degranulation rate and degree, MC disintegration closer to the center of the tumor, together with the appearance in the peritumorous tissues, in the tumor itself, and in RLN of numerous small, immature MC, by their morphometric parameters identical to the intestinal mucosal MC, may presumably indicate the decompensation phenomena in the system and of the approaching of process terminal stage.
采用光镜和电镜方法，对120只体重120 - 150克的远交系雌性白化大鼠在皮下注射化学致癌物N - 甲基 - N - 亚硝基脲诱导乳腺癌（BC）不同阶段时，乳腺（MG）和区域淋巴结（RLN）中肥大细胞（MC）群体的形态计量学和功能特征进行了研究。在研究的BC形成的所有阶段（致癌物暴露64 - 180天），发现MG和RLN中的MC数量和活性均增加。MC脱粒率和程度逐渐增加，MC解体更靠近肿瘤中心，同时在肿瘤周围组织、肿瘤本身以及RLN中出现大量形态计量学参数与肠黏膜MC相同的小的、未成熟的MC，这可能预示着该系统出现失代偿现象以及病程接近末期。
