Deugnier Y, Battistelli D, Jouanolle H, Guyader D, Gueguen M, Loréal O, Jacquelinet C, Bourel M, Brissot P
Clinique des Maladies du Foie, and INSERM U49, CHRU, Hôpital Pontchaillou, Rennes, France.
J Hepatol. 1991 Nov;13(3):286-90. doi: 10.1016/0168-8278(91)90070-r.
Serum hepatitis B virus (HBV) infection markers were studied in 272 patients with homozygous genetic haemochromatosis complicated (n = 33) or not (n = 239) with primary liver cancer (PLC). Controls consisted of 255 029 healthy blood donors from whom age- and sex-matched control groups were extracted for statistical evaluation using the Fisher exact test. In blood donors, HBsAg was positive in 0.075% of males and 0.04% of females. This population was not screened for anti-Hbs. Anti-Hbc alone (without HBsAg) was present in 3.7% of men and 1.8% of women. In patients with genetic haemochromatosis without liver cancer (183 males, 45.6 +/- 11.3 yrs and 56 women, 48 +/- 12.4 yrs), HBsAg was found in 1.1% of men and in none of the women. Anti-HBs was present in 7.3% of males and 1.8% of females. Anti-HBc alone was found in 13% of males (p less than 0.005 vs. controls) and 2.1% of females. From male patients with primary liver cancer complicating genetic haemochromatosis (32 males, 61.7 +/- 6.8 yrs and one female), 6.2% were HBsAg positive, 3.4% were anti-HBs positive and 16.6% anti-HBc positive (p = 0.05 vs. controls). No serum HBV marker was found in the woman. In conclusion, the prevalence of HBV infection markers--especially anti-HBc--is significantly increased in patients with genetic haemochromatosis complicated or not with primary liver cancer.
对272例患有纯合子遗传性血色素沉着症且合并（n = 33）或未合并（n = 239）原发性肝癌（PLC）的患者，研究了血清乙肝病毒（HBV）感染标志物。对照组由255029名健康献血者组成，从中提取年龄和性别匹配的对照组，采用Fisher精确检验进行统计评估。在献血者中，HBsAg在0.075%的男性和0.04%的女性中呈阳性。该人群未进行抗-Hbs筛查。单独抗-Hbc（无HBsAg）在3.7%的男性和1.8%的女性中存在。在无肝癌的遗传性血色素沉着症患者中（183名男性，45.6±11.3岁，56名女性，48±12.4岁），1.1%的男性中发现HBsAg，女性中未发现。抗-HBs在7.3%的男性和1.8%的女性中存在。单独抗-HBc在13%的男性中发现（与对照组相比p<0.005），在2.1%的女性中发现。在合并遗传性血色素沉着症的原发性肝癌男性患者中（32名男性，61.7±6.8岁，1名女性），6.2%的患者HBsAg呈阳性，3.4%的患者抗-HBs呈阳性，16.6%的患者抗-HBc呈阳性（与对照组相比p = 0.05）。该女性患者未发现血清HBV标志物。总之，无论是否合并原发性肝癌，遗传性血色素沉着症患者中HBV感染标志物尤其是抗-HBc的患病率均显著增加。
