Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, Münster, Germany; Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Neurology with Institute of Translational Neurology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Münster, Germany.
Nutrition. 2021 Feb;82:111047. doi: 10.1016/j.nut.2020.111047. Epub 2020 Nov 6.
Preliminary studies indicate that a robust immune response across different cell types is crucial in recovery from coronavirus disease 2019 (COVID-19). An enormous number of investigations point to the vital importance of various micronutrients in the interactions between the host immune system and viruses, including COVID-19. There are complex and multifaceted links among micronutrient status, the host immune response, and the virulence of pathogenic viruses. Micronutrients play a critical role in the coordinated recruitment of innate and adaptive immune responses to viral infections, particularly in the regulation of pro- and anti-inflammatory host responses. Furthermore, inadequate amounts of micronutrients not only weaken the immune system in combating viral infections, but also contribute to the emergence of more virulent strains via alterations of the genetic makeup of the viral genome. The aim of this study was to evaluate the evidence that suggests the contribution of micronutrients in the spread as well as the morbidity and mortality of COVID-19. Both the presence of micronutrient deficiencies among infected individuals and the effect of micronutrient supplementation on the immune responses and overall outcome of the disease could be of great interest when weighing the use of micronutrients in the prevention and treatment of COVID-19 infection. These investigations could be of great value in dealing with future viral epidemics.
初步研究表明，在从 2019 年冠状病毒病（COVID-19）中康复过程中，不同类型的细胞中产生强大的免疫反应至关重要。大量研究表明，各种微量营养素在宿主免疫系统与病毒（包括 COVID-19）之间的相互作用中具有至关重要的意义。微量营养素状况、宿主免疫反应和致病病毒的毒力之间存在复杂且多方面的联系。微量营养素在协调先天和适应性免疫反应对病毒感染的反应中起着关键作用，特别是在调节宿主的促炎和抗炎反应方面。此外，微量营养素的摄入量不足不仅会削弱免疫系统对抗病毒感染的能力，还会通过改变病毒基因组的遗传结构导致更具毒性的病毒株的出现。本研究旨在评估微量营养素在 COVID-19 传播、发病率和死亡率方面的作用的证据。在权衡微量营养素在 COVID-19 感染的预防和治疗中的应用时，感染个体中存在微量营养素缺乏以及补充微量营养素对免疫反应和疾病整体结果的影响都可能非常重要。这些研究对于应对未来的病毒流行具有重要价值。
