Onodera A, Shioya T, Miura S, Kagaya M, Yoshida K, Miura K, Miura M
Department of Respiratory Medicine, Yuri Kumiai General Hospital, Honjo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Dec;29(12):1538-46.
In order to evaluate isometric tension in segments of tracheal smooth muscle in vivo, we first investigated the anatomical distribution of arteries supplying the tracheal smooth muscle in 52 dogs. The patterns of the cranial thyroid arteries were classified into the following four types. A) Common type: the cranial thyroid artery leaves the muscular branch, and then divides into the thyroid branch and the tracheal branch. B) The cranial thyroid artery leaves the tracheal branch, and then divides into the muscular branch and the thyroid branch. C) The cranial thyroid artery divides into the muscular branch, the thyroid branch, and the tracheal branch. D) The cranial thyroid artery divides into the tracheal branch and thyroid branch, and lacks a muscular branch. Out of 52 dogs, 62% had common type bilaterally, and 23% had common type unilaterally. All dogs had a tracheal branch. We demonstrated tracheal smooth muscle contraction by intra-arterial administration of acetylcholine, histamine, 5-hydroxy-tryptamine, phenylephrine, and clonidine using isometric technique in vivo. These results suggest that tracheal contraction induced by sympathetic amines is mediated through two subtypes of receptors, alpha 1 and alpha 2, in tracheal smooth muscle.
为了评估体内气管平滑肌段的等长张力，我们首先在52只犬中研究了供应气管平滑肌的动脉的解剖分布。甲状腺上动脉的模式分为以下四种类型。A）常见类型：甲状腺上动脉发出肌支，然后分为甲状腺支和气管支。B）甲状腺上动脉发出气管支，然后分为肌支和甲状腺支。C）甲状腺上动脉分为肌支、甲状腺支和气管支。D）甲状腺上动脉分为气管支和甲状腺支，且无肌支。在52只犬中，62%双侧为常见类型，23%单侧为常见类型。所有犬均有气管支。我们在体内使用等长技术通过动脉内给予乙酰胆碱、组胺、5-羟色胺、去氧肾上腺素和可乐定来证明气管平滑肌收缩。这些结果表明，交感胺诱导的气管收缩是通过气管平滑肌中的两种受体亚型α1和α2介导的。
