Banning Christopher S, Kim Woon Cho, Randleman J Bradley, Kim Eung Kweon, Stulting R Doyle
Department of Ophthalmology, Emory University, Atlanta, GA, USA.
Cornea. 2006 May;25(4):482-4. doi: 10.1097/01.ico.0000195949.93695.37.
To report the first case of Avellino corneal dystrophy exacerbation after LASIK in a white or North American patient.
Case report and literature review.
A 25-year-old white female developed progressive corneal opacities after LASIK. Preoperative examination had revealed only subtle white corneal opacities in each eye. The patient's mother had similar corneal opacities. DNA analysis of the patient revealed a heterozygous mutation at the R124H location in the BIGH3 gene.
LASIK can exacerbate Avellino corneal dystrophy and should be avoided in patients with this condition. A careful history and genetic analysis can identify affected patients and those at risk.
报告首例白人或北美患者在准分子激光原位角膜磨镶术（LASIK）后阿韦利诺角膜营养不良病情加重的病例。
病例报告及文献综述。
一名25岁白人女性在LASIK术后出现进行性角膜混浊。术前检查仅发现每只眼睛有细微的白色角膜混浊。患者的母亲有类似的角膜混浊。对该患者的DNA分析显示，在BIGH3基因的R124H位置存在杂合突变。
LASIK可使阿韦利诺角膜营养不良病情加重，患有这种疾病的患者应避免接受该手术。详细的病史和基因分析可识别受影响的患者及有风险的人群。
