Teper Alejandro Manuel, Kofman Carlos Daniel
Respiratory Center, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina.
Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):152-4. doi: 10.1097/01.all.0000225151.99284.cd.
To report on recent studies on the effect of inhaled corticosteroids on pulmonary function in young children with asthma.
Inhaled corticosteroids are considered the most effective treatment for persistent asthma in children. Appropriate control of childhood asthma may prevent more serious disease or irreversible obstruction in later years. While some authors have described an improvement with the use of inhaled corticosteroids in young children, others found no clinical or functional benefit. Various studies have shown that inhaled corticosteroids ameliorate clinical outcomes, and recently a study demonstrated improvement in pulmonary function in young children with asthma. The use of different study designs may explain the lack of consistent results and disagreement regarding the efficacy of inhaled corticosteroids in these patients.
Based on the preponderance of evidence, treatment with inhaled corticosteroids in infants and young children with recurrent wheeze and risk factors of developing asthma appears to allow better control of the illness and improve the pulmonary function.
报告近期关于吸入性糖皮质激素对哮喘幼儿肺功能影响的研究。
吸入性糖皮质激素被认为是治疗儿童持续性哮喘最有效的方法。适当控制儿童哮喘可预防日后更严重的疾病或不可逆性阻塞。虽然一些作者描述了吸入性糖皮质激素在幼儿中的使用有改善，但其他作者未发现临床或功能上的益处。各种研究表明吸入性糖皮质激素可改善临床结局，最近一项研究证明哮喘幼儿的肺功能有所改善。不同的研究设计可能解释了在这些患者中关于吸入性糖皮质激素疗效缺乏一致结果和存在分歧的原因。
基于大量证据，对有反复喘息和发展为哮喘风险因素的婴幼儿使用吸入性糖皮质激素治疗似乎能更好地控制病情并改善肺功能。
