Dubick Michael A, Bruttig Stephen P, Wade Charles E
US Army Institute of Surgical Research, Fort Sam Houston, TX, USA.
Shock. 2006 Apr;25(4):321-8. doi: 10.1097/01.shk.0000209525.50990.28.
Small volume resuscitation fluids continue to be of interest to the military and limited volume resuscitation is becoming more common in the treatment of hemorrhage in the civilian community. With renewed interest to undertake a large US-Canada multi-center clinical trial of hypertonic saline alone or combined with dextran (HSD) possibly in 2006, concerns related to the safe use of this product continue to surface. This review addresses the use of these products in uncontrolled hemorrhage models, in dehydration and addresses perceived risks associated with hypernatremia, dextran-associated anaphylactoid reactions and effects on coagulation and renal function.
小容量复苏液仍然受到军方的关注，在平民社区治疗出血时，限量复苏正变得越来越普遍。随着人们重新有兴趣可能在2006年开展一项美国 - 加拿大关于单独使用高渗盐水或与右旋糖酐联合使用（高渗盐水右旋糖酐合剂）的多中心临床试验，与该产品安全使用相关的问题不断出现。这篇综述探讨了这些产品在失血性休克未控制模型、脱水情况中的应用，并阐述了与高钠血症、右旋糖酐相关类过敏反应以及对凝血和肾功能影响相关的潜在风险。
