创伤后使用高渗盐水院前复苏的 ROC 试验更新：来自美加试验后的结果。
ROC trials update on prehospital hypertonic saline resuscitation in the aftermath of the US-Canadian trials.
机构信息
U.S. Army Institute of Surgical Research, San Antonio, TX, USA.
出版信息
Clinics (Sao Paulo). 2013 Jun;68(6):883-6. doi: 10.6061/clinics/2013(06)25.
Abstract
The objectives of this review are to assess the current state of hypertonic saline as a prehospital resuscitation fluid in hypotensive trauma patients, particularly after the 3 major Resuscitation Outcomes Consortium trauma trials in the US and Canada were halted due to futility. Hemorrhage and traumatic brain injury are the leading causes of death in both military and civilian populations. Prehospital fluid resuscitation remains controversial in civilian trauma, but small-volume resuscitation with hypertonic fluids is of utility in military scenarios with prolonged or delayed evacuation times. A large body of pre-clinical and clinical literature has accumulated over the past 30 years on the hemodynamic and, most recently, the anti-inflammatory properties of hypertonic saline, alone or with dextran-70. This review assesses the current state of hypertonic fluid resuscitation in the aftermath of the failed Resuscitation Outcomes Consortium trials.
摘要
本次综述的目的在于评估高渗盐水作为创伤性低血压患者院前复苏液的现状，尤其是在美国和加拿大的 3 项主要复苏结局联合会创伤试验因无效而停止之后。出血和创伤性脑损伤是军队和平民人群中导致死亡的主要原因。院前液体复苏在平民创伤中仍存在争议，但在需要长时间或延迟后送的军事场景中，小容量高渗液复苏具有一定作用。在过去的 30 年中，积累了大量关于高渗盐水的临床前和临床文献，涉及到其血流动力学作用，以及最近涉及到的高渗盐水与右旋糖酐-70 联合应用的抗炎作用。本综述评估了复苏结局联合会试验失败后高渗液复苏的现状。
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