[凝血酶和胰蛋白酶对L-精氨酸N-芳基磺酰基衍生物甲酯的水解作用]
[Hydrolysis of the methyl esters of the N-arylsulfonyl derivatives of L-arginine by thrombin and trypsin].
作者信息
Serebrianyĭ S B, Kibirev V K, Sereĭskaia A A, Fedoriak D M
出版信息
Biokhimiia. 1975 Jan-Feb;40(1):103-6.
PMID:166707
Abstract
Trypsin- and thrombin-catalysed hydrolysis of the Nalpha-aryl-sulfonyl-L-arginine methyl esters was studied. Michaelis constants and kcat were determined. The hydrolysis of the substrates by trypsin appears to depend on the polar nature of substitutes. The thrombin- catalysed reaction was believed to be sensitive to steric effects of the introducted groups.
摘要
研究了胰蛋白酶和凝血酶催化的Nα-芳基磺酰基-L-精氨酸甲酯的水解反应。测定了米氏常数和催化常数。胰蛋白酶对底物的水解似乎取决于取代基的极性。凝血酶催化的反应被认为对引入基团的空间效应敏感。
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