Kibirev V K, Sereĭskaia A A, Romanova V P, Serebrianyĭ S B
Biokhimiia. 1979 Apr;44(4):616-21.
The esterase action of thrombin and trypsin on N-arylsulfonyl-valyl-arginine methyl esters was studied. The values of Km and kcat under steady-state conditions at pH 8,5 were determined. It was shown that the nature of the arylsulfonyl group does not affect the kinetic parameters of the reactions under study. The Michaelis constants of the thrombin-catalyzed reactions appeared to be one order of magnitude lower than the Km values of the corresponding TAME analogs.
研究了凝血酶和胰蛋白酶对N-芳基磺酰基-缬氨酰-精氨酸甲酯的酯酶作用。测定了在pH 8.5的稳态条件下的Km和kcat值。结果表明，芳基磺酰基的性质不影响所研究反应的动力学参数。凝血酶催化反应的米氏常数似乎比相应的TAME类似物的Km值低一个数量级。
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