Hartmann Anders, Holdaas Hallvard, Os Ingrid, Hunderi Odd Helge, Hallan Stein, Widerøe Tor Erik, Svarstad Einar, Selvig Kristian, Skjønsberg Helge, Toft Ingrid
Nyreseksjonen, Medisinsk avdeling, Rikshospitalet.
Tidsskr Nor Laegeforen. 2006 Apr 27;126(9):1198-200.
Kidney failure has traditionally been categorised as mild, moderate or severe. Other poorly defined terms like uraemia and end-stage kidney disease have commonly been applied. During the last few years, an international consensus has emerged staging chronic kidney disease into 5 stages: stage 1 being glomerular filtration rate (GFR) > 90 ml/min and signs of kidney damage, stage 2 GFR 60-89 ml/min and signs of kidney damage, stage 3 being GFR 30-59 ml/min, stage 4 being GFR 15-29 ml/min, and stage 5 GFR < 15 ml/min. Kidney function should be calculated from creatinine-based formulas, or measured by isotope or iohexol clearances rather than as renal clearance of creatinine in timed urine samples. We address the importance and implications of these new definitions.
传统上，肾衰竭被分为轻度、中度或重度。诸如尿毒症和终末期肾病等其他定义不明确的术语也经常被使用。在过去几年中，国际上已达成共识，将慢性肾病分为5期：1期为肾小球滤过率（GFR）>90 ml/分钟且有肾脏损伤迹象；2期为GFR 60 - 89 ml/分钟且有肾脏损伤迹象；3期为GFR 30 - 59 ml/分钟；4期为GFR 15 - 29 ml/分钟；5期为GFR<15 ml/分钟。肾功能应根据基于肌酐的公式计算，或通过同位素或碘海醇清除率测量，而不是通过定时尿样中肌酐的肾清除率来测定。我们阐述了这些新定义的重要性及影响。
