Nain C K, Dutt P, Vinayak V K
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Ann Trop Med Parasitol. 1991 Oct;85(5):515-22. doi: 10.1080/00034983.1991.11812602.
Decline in the specific activities of intestinal cytosolic glucose-6-phosphate dehydrogenase (G6PD) and isocitrate dehydrogenase (ICDH); brush border glucoamylase, and isomaltase; and basolateral (Na+, K+)-ATPase activities were observed during the establishment, acute phase and decline phase of infection in Giardia lamblia-infected mice. The degree of decline in the activities of various enzymes correlated well with the number of trophozoites counted in the jejunum. There appeared to be a gradual recovery of enzymatic activities during the decline phase of infection, when the number of trophozoites also declined. The decline in activities of these enzymes may contribute to malabsorption of nutrients during giardiasis.
在感染蓝氏贾第鞭毛虫的小鼠中，观察到肠道胞质葡萄糖-6-磷酸脱氢酶（G6PD）和异柠檬酸脱氢酶（ICDH）、刷状缘葡糖淀粉酶和异麦芽糖酶以及基底外侧（Na +，K +）-ATP酶活性在感染的建立期、急性期和衰退期均有所下降。各种酶活性的下降程度与空肠中滋养体的数量密切相关。在感染衰退期，当滋养体数量也下降时，酶活性似乎逐渐恢复。这些酶活性的下降可能导致贾第虫病期间营养物质的吸收不良。
