Khanna R, Vinayak V K, Mehta S, Nain C K
Department of Experimental Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Dig Dis Sci. 1988 Sep;33(9):1147-52. doi: 10.1007/BF01535792.
NMRI mice immunosuppressed with dexamethasone followed by challenge intraesophageally with axenic Giardia lamblia (Portland I) trophozoites had severe infection in terms of the trophozoite counts in the jejunum. Although the immunosuppressive treatment with cortisone itself resulted in a deleterious effect on brush border membrane enzymes, the decline in disaccharidases (sucrase, maltase, and lactase) and alkaline phosphatase was highly significant (P less than 0.001) following G. lamblia infection. The alterations in enzymatic activity in immune intact but infected animals demonstrated the potential of the parasite itself to cause damage to the brush border membrane. We believe that individuals with underlying immunodeficiency, upon infection with G. lamblia, may have increased damage of the brush border membrane, leading to severe malabsorption.
用 dexamethasone 免疫抑制的 NMRI 小鼠，随后经食管接种无菌的蓝氏贾第鞭毛虫（波特兰 I 型）滋养体，就空肠内滋养体数量而言，感染严重。尽管用可的松进行免疫抑制治疗本身对刷状缘膜酶有有害影响，但感染蓝氏贾第鞭毛虫后，双糖酶（蔗糖酶、麦芽糖酶和乳糖酶）和碱性磷酸酶的下降非常显著（P 小于 0.001）。免疫功能正常但受感染动物的酶活性改变表明，寄生虫本身有破坏刷状缘膜的可能性。我们认为，有潜在免疫缺陷的个体感染蓝氏贾第鞭毛虫后，可能会增加刷状缘膜的损伤，导致严重的吸收不良。
