Adams P M, Barratt E S
Biol Psychiatry. 1975 Jun;10(3):315-22.
The effects of the repeated administration of delta-9-tetrahydrocannabinol on sleep-wakefulness patterns were studied in adult male squirrel monkeys. The percent time spent in slow wave sleep was reduced with chronic treatment and failed to return to base line levels after 30 days of recovery. The amount of time spent in Stage 1 or drowsy state increased with repeated treatment and remained elevated through recovery. Changes observed in other stages of sleep-wakefulness were sensitive to repeated treatment with marijuana but were found to return to base line levels during recovery.
在成年雄性松鼠猴中研究了反复给予Δ⁹-四氢大麻酚对睡眠-觉醒模式的影响。长期治疗后，慢波睡眠所花时间百分比降低，且在恢复30天后未能恢复到基线水平。反复治疗后，处于第1阶段或困倦状态所花时间增加，且在恢复过程中一直居高不下。在睡眠-觉醒的其他阶段观察到的变化对大麻反复治疗敏感，但在恢复过程中恢复到基线水平。
