含有4-乙氧基-3-吡咯啉-2-酮的二肽类似物。

Dipeptide analogues containing 4-ethoxy-3-pyrrolin-2-ones.

作者信息

Hosseini Masood, Kringelum Henriette, Murray Anthony, Tønder Janne E

机构信息

Medicinal Chemistry Research, Novo Nordisk A/S, Måløv, Denmark.

出版信息

Org Lett. 2006 May 11;8(10):2103-6. doi: 10.1021/ol060500i.

DOI:10.1021/ol060500i

PMID:16671792

Abstract

[reaction: see text] Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.

摘要

[反应：见正文] 吡咯烷-2,4-二酮（1）是天然存在的氨基酸类似物。我们在此展示了一种高产率且对映体纯度优异的N-酰化、O-烷基化吡咯啉-2-酮（2）的简便合成方法。分子力学计算表明，所得的二肽类似物呈现线性、伸展的构象。