乙酰胆碱对兔耳动脉肾上腺素能传递的调节作用。
Modulation by acetylcholine of adrenergic transmission in the rabbit ear artery.
作者信息
Allen G S, Glover A B, McCulloch M W, Rand M J, Story D F
出版信息
Br J Pharmacol. 1975 May;54(1):49-53. doi: 10.1111/j.1476-5381.1975.tb07408.x.
Abstract
- Low concentrations of acetylcholine (4 times 10(-11) and 1 times 10(-10) M) increase the vasoconstrictor response of the isolated ear artery of the rabbit to stimulation of the periarterial sympathetic nerves. Higher concentrations (4 times 10(-8) M and greater) decrease the response. 2. Low concentrations of acetylcholine (1 times 10(-11) and 1 times 10(-10) M) increase the stimulation-induced efflux of radioactivity from artery segments previously incubated with [3H]-noradrenaline. Higher ocncentrations (3 times 10(-8) M and greater) decrease the efflux. 3. Neither atropine nor hexamethonium affects the facilitatory action of low concentrations of acetylcholine on adrenergic transmission in the rabbit ear artery. 4. Atropine antagonizes the inhibitory effect of higher concentrations of acetylcholine on adrenergic transmission.
摘要
- 低浓度的乙酰胆碱（4×10⁻¹¹和1×10⁻¹⁰M）可增强兔离体耳动脉对动脉周围交感神经刺激的血管收缩反应。较高浓度（4×10⁻⁸M及更高）则降低该反应。2. 低浓度的乙酰胆碱（1×10⁻¹¹和1×10⁻¹⁰M）可增加先前用[³H] - 去甲肾上腺素孵育的动脉段中刺激诱导的放射性流出。较高浓度（3×10⁻⁸M及更高）则降低流出量。3. 阿托品和六甲铵均不影响低浓度乙酰胆碱对兔耳动脉肾上腺素能传递的促进作用。4. 阿托品可拮抗较高浓度乙酰胆碱对肾上腺素能传递的抑制作用。
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本文引用的文献
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Br J Pharmacol Chemother. 1960 Mar;15(1):56-66. doi: 10.1111/j.1476-5381.1960.tb01210.x.
2
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Br J Pharmacol. 1970 Apr;38(4):758-70. doi: 10.1111/j.1476-5381.1970.tb09885.x.
3
Effect of acetylcholine on the response of the isolated rabbit ear artery to stimulation of the perivascular sympathetic nerves.乙酰胆碱对离体兔耳动脉对血管周围交感神经刺激反应的影响。
Eur J Pharmacol. 1972 Feb;17(2):227-33. doi: 10.1016/0014-2999(72)90163-x.
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Comparison of effects of six cholinomimetic drugs on inhibition of uptake of 3 H-( )-noradrenaline by guinea-pig atria.六种拟胆碱药物对豚鼠心房抑制3H-（）-去甲肾上腺素摄取作用的比较。 （注：原文括号处内容缺失）
Br J Pharmacol. 1973 Jan;47(1):179-80. doi: 10.1111/j.1476-5381.1973.tb08172.x.
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