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六种拟胆碱药物对豚鼠心房抑制3H-（）-去甲肾上腺素摄取作用的比较。 （注：原文括号处内容缺失）

Comparison of effects of six cholinomimetic drugs on inhibition of uptake of 3 H-( )-noradrenaline by guinea-pig atria.

作者信息

Allen G S, Rand M J, Story D F

出版信息

Br J Pharmacol. 1973 Jan;47(1):179-80. doi: 10.1111/j.1476-5381.1973.tb08172.x.

DOI:10.1111/j.1476-5381.1973.tb08172.x
PMID:4717017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776528/
Abstract

The effects of N,N-dimethyl-N'-phenyl-piperazinium (DMPP), 4-(m-chlorophenyl-carbamoyloxy) - 2 - butynyltrimethylammonium chloride (McN-A-343), pilocarpine, acetylcholine, methacholi-ne and nicotine in inhibiting the uptake of (3)H-(+/-)-noradrenaline by guinea-pig atria were compared. In concentrations of 1 x 10(-4)M, the percentage inhibitions were as follows: DMPP, 89.1%; McN-A-343, 78.7%; pilocarpine 43.5%; acetylcholine, 35.7%; methacholine, 32.9%; nicotine, 21.6%.

摘要

比较了N，N-二甲基-N'-苯基哌嗪鎓（DMPP）、4-（间氯苯基氨甲酰氧基）-2-丁炔基三甲基氯化铵（McN-A-343）、毛果芸香碱、乙酰胆碱、醋甲胆碱和尼古丁对豚鼠心房摄取（3）H-（+/-）-去甲肾上腺素的抑制作用。在1×10（-4）M的浓度下，抑制百分比分别如下：DMPP为89.1%；McN-A-343为78.7%；毛果芸香碱为43.5%；乙酰胆碱为35.7%；醋甲胆碱为32.9%；尼古丁为21.6%。

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1
Comparison of effects of six cholinomimetic drugs on inhibition of uptake of 3 H-( )-noradrenaline by guinea-pig atria.六种拟胆碱药物对豚鼠心房抑制3H-（）-去甲肾上腺素摄取作用的比较。 （注：原文括号处内容缺失）
Br J Pharmacol. 1973 Jan;47(1):179-80. doi: 10.1111/j.1476-5381.1973.tb08172.x.
2
Effects of McN-A-343 and DMPP on the uptake and release of 3 H-noradrenaline by guinea-pig atria.McN - A - 343和二甲基苯基哌嗪对豚鼠心房摄取和释放3H - 去甲肾上腺素的影响。
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引用本文的文献

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Interaction between the inhibitory action of acetylcholine and the alpha-adrenoceptor autoinhibitory feedback system on release of [3H]-noradrenaline from rat atria and rabbit ear artery.乙酰胆碱的抑制作用与α-肾上腺素能受体自身抑制反馈系统对大鼠心房和兔耳动脉中[3H]-去甲肾上腺素释放的相互作用。
Br J Pharmacol. 1985 Mar;84(3):697-705. doi: 10.1111/j.1476-5381.1985.tb16152.x.
2
Modulation by acetylcholine of adrenergic transmission in the rabbit ear artery.乙酰胆碱对兔耳动脉肾上腺素能传递的调节作用。
Br J Pharmacol. 1975 May;54(1):49-53. doi: 10.1111/j.1476-5381.1975.tb07408.x.

本文引用的文献

1
Modification by acetylcholine of the response of rat mesenteric arteries to sympathetic stimulation.乙酰胆碱对大鼠肠系膜动脉交感神经刺激反应的调节作用。
Circ Res. 1969 Jul;25(1):1-9. doi: 10.1161/01.res.25.1.1.
2
A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents.一种毒蕈碱机制，通过烟碱样物质抑制外周肾上腺素能神经纤维释放去甲肾上腺素。
Br J Pharmacol Chemother. 1968 Feb;32(2):280-94. doi: 10.1111/j.1476-5381.1968.tb00972.x.
3
The effects of cholinomimetic drugs on responses to sympathetic nerve stimulation and noradrenaline in the rabbit ear artery.拟胆碱药物对兔耳动脉交感神经刺激反应及去甲肾上腺素的影响。
Br J Pharmacol. 1970 Apr;38(4):758-70. doi: 10.1111/j.1476-5381.1970.tb09885.x.
4
Effects of the muscarinic agonist McN-A-343 on responses to sympathetic nerve stimulation in the rabbit ear artery.毒蕈碱激动剂 McN-A-343 对兔耳动脉交感神经刺激反应的影响。
Br J Pharmacol. 1971 Nov;43(3):536-42. doi: 10.1111/j.1476-5381.1971.tb07183.x.
5
Effects of McN-A-343 and DMPP on the uptake and release of 3 H-noradrenaline by guinea-pig atria.McN - A - 343和二甲基苯基哌嗪对豚鼠心房摄取和释放3H - 去甲肾上腺素的影响。
Br J Pharmacol. 1972 Jul;45(3):480-9. doi: 10.1111/j.1476-5381.1972.tb08105.x.
6
Modification of the vascular response to isoprenaline by cholinomimetic drugs.拟胆碱药对血管对异丙肾上腺素反应的影响
Br J Pharmacol. 1971 Jun;42(2):254-62. doi: 10.1111/j.1476-5381.1971.tb07106.x.