Ni Mhurchu Cliona, Parag Varsha, Nakamura Mieko, Patel Anushka, Rodgers Anthony, Lam Tai Hing
Asia Pac J Clin Nutr. 2006;15(2):127-33.
Few prospective data from the Asia Pacific region are available relating body mass index to the risk of diabetes. Our objective was to provide reliable age, sex and region specific estimates of the associations between body mass index and diabetes. Twenty-seven cohort studies from Asia, New Zealand and Australia, including 154,989 participants, contributed 1,244,793 person-years of follow-up. Outcome data included a combination of incidence of diabetes (based on blood glucose measurements) and fatal diabetes events. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. During follow-up (mean = 8 years), 75 fatal diabetes events and 242 new cases of diabetes were documented. There were continuous positive associations between baseline body mass index and risk of diabetes with each 2 kg/m2 lower body mass index associated with a 27% (23-30%) lower risk of diabetes. The associations were stronger in younger age groups, and regional comparisons demonstrated slightly stronger associations in Asian than in Australasian cohorts (P = 0.04). This overview provides evidence of a strong continuous association between body mass index and diabetes in the Asia Pacific region. The results indicate considerable potential for reduction in incidence of diabetes with population-wide lowering of body mass index in this region.
亚太地区关于体重指数与糖尿病风险的前瞻性数据较少。我们的目标是提供可靠的按年龄、性别和地区划分的体重指数与糖尿病之间关联的估计值。来自亚洲、新西兰和澳大利亚的27项队列研究，包括154,989名参与者，提供了1,244,793人年的随访数据。结局数据包括糖尿病发病率（基于血糖测量）和糖尿病致死事件的综合情况。风险比通过Cox模型计算，按性别和队列分层，并根据风险年龄和吸烟情况进行调整。在随访期间（平均8年），记录了75例糖尿病致死事件和242例新的糖尿病病例。基线体重指数与糖尿病风险之间存在持续的正相关，体重指数每降低2kg/m²，糖尿病风险降低27%（23%-30%）。这种关联在较年轻年龄组中更强，地区比较显示，亚洲队列中的关联略强于澳大拉西亚队列（P=0.04）。本综述提供了证据，证明亚太地区体重指数与糖尿病之间存在强烈的持续关联。结果表明，通过在该地区全体人群中降低体重指数，糖尿病发病率有相当大的降低潜力。
