Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, 462020, India.
Independent Researcher, Bhopal, Madhya Pradesh, 462020, India.
Curr Diabetes Rev. 2024;20(7):e251023222697. doi: 10.2174/0115733998262501231015051317.
Type 2 diabetes (T2D), a multifaceted metabolic disorder, may cause health tribulations and changes in biochemical blood markers. Other research has examined the relationships between several biomarkers and the risk of T2D. Few studies have examined the relationships between these biomarkers and potential changes to the network of biomarkers associated with diabetes.
Glycated hemoglobin, or HbA1c, is used to evaluate and track the blood glucose history throughout the previous two to three months of testing. The ability to reflect the cumulative glycemic history of the previous two to three months makes HbA1c an essential biomarker of long-term glycemic control. HbA1c offers a trustworthy indicator of chronic hyperglycemia and strongly correlates with the likelihood of long-term consequences from diabetes.
Additionally, elevated HbA1c has been recognized as a stand-alone risk factor for patients with and without diabetes developing coronary heart disease and stroke. One HbA1c test offers a wealth of information that makes it a reliable biomarker for the diagnosis and prognosis of diabetes. A clinical examination may be required to establish the connection between diabetes, prediabetes, biochemical blood indicators, age, and body mass index (BMI).
We observed that diabetes, BMI, age, HbA1c, cholesterol, triglycerides, LDL, VLDL, and HDL were all linked using multivariate analysis.
2 型糖尿病（T2D）是一种多方面的代谢紊乱，可能会导致健康问题和生化血液标志物的变化。其他研究已经检查了几种生物标志物与 T2D 风险之间的关系。很少有研究检查这些生物标志物与糖尿病相关生物标志物网络的潜在变化之间的关系。
糖化血红蛋白（HbA1c）用于评估和跟踪过去两到三个月测试期间的血糖历史。HbA1c 能够反映过去两到三个月的累积血糖历史，因此是长期血糖控制的重要生物标志物。HbA1c 是慢性高血糖的可靠指标，与糖尿病的长期后果发生的可能性密切相关。
此外，HbA1c 升高已被认为是糖尿病和非糖尿病患者发生冠心病和中风的独立危险因素。一次 HbA1c 检测提供了丰富的信息，使其成为诊断和预测糖尿病的可靠生物标志物。可能需要进行临床检查以确定糖尿病、糖尿病前期、生化血液指标、年龄和体重指数（BMI）之间的联系。
我们观察到糖尿病、BMI、年龄、HbA1c、胆固醇、甘油三酯、LDL、VLDL 和 HDL 均通过多变量分析相关。
