非产毒白喉棒状杆菌侵袭性克隆在加拿大温哥华城市贫困人口中的出现。
Emergence of an invasive clone of nontoxigenic Corynebacterium diphtheriae in the urban poor population of Vancouver, Canada.
作者信息
Romney M G, Roscoe D L, Bernard K, Lai S, Efstratiou A, Clarke A M
机构信息
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
出版信息
J Clin Microbiol. 2006 May;44(5):1625-9. doi: 10.1128/JCM.44.5.1625-1629.2006.
Abstract
Invasive disease due to Corynebacterium diphtheriae is rare in North America. Here we describe the emergence of a predominant clone of a nontoxigenic strain of C. diphtheriae in the impoverished population of Vancouver's downtown core. This clone has caused significant morbidity and contributed to at least two deaths. Over a 5-year period, seven cases of bacteremia due to C. diphtheriae were detected in patients admitted to Vancouver hospitals. Injection drug use, diabetes mellitus, skin colonization/infection with C. diphtheriae, and homelessness all appeared to be related to the development of bacteremia with the organism. Ribotyping of isolates recovered from blood culture revealed a predominant ribotype pattern that has not previously been reported in North America.
摘要
北美地区由白喉棒状杆菌引起的侵袭性疾病较为罕见。在此，我们描述了温哥华市中心核心贫困人群中出现的一种非产毒白喉棒状杆菌优势克隆。该克隆已导致显著发病，并造成至少两例死亡。在5年期间，温哥华各医院收治的患者中检测到7例白喉棒状杆菌菌血症病例。注射吸毒、糖尿病、白喉棒状杆菌皮肤定植/感染以及无家可归似乎都与该菌引起的菌血症发生有关。从血培养中分离出的菌株进行核糖体分型显示出一种北美此前未报道过的优势核糖体分型模式。
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