Reacher Mark, Ramsay Mary, White Joanne, De Zoysa Aruni, Efstratiou Androulla, Mann Gina, Mackay Andrew, George Robert C
Public Health Laboratory Service, London, United Kingdom.
Greenwich District General Hospital, Vanbrugh Hill, London, United Kingdom.
Emerg Infect Dis. 2000 Nov-Dec;6(6):640-645. doi: 10.3201/eid0606.000614.
Confirmed isolates of nontoxigenic Corynebacterium diphtheriae in England and Wales increased substantially from 1986 to 1994. Ribotyping of 121 isolates confirmed in 1995 showed that 90 were of a single strain isolated exclusively from the throat; none had previously been identified in toxigenic strains from U.K. or non-U.K. residents. The upward trend in nontoxigenic C. diphtheriae probably represented increased ascertainment, although dissemination of a particular strain or clone may have been a factor.
1986年至1994年间,英格兰和威尔士确诊的非产毒性白喉棒状杆菌分离株大幅增加。1995年对121株确诊分离株进行的核糖体分型显示,其中90株属于单一菌株,仅从咽喉部分离得到;此前在英国或非英国居民的产毒菌株中均未发现过这些菌株。非产毒性白喉棒状杆菌的上升趋势可能代表着确诊率的提高,尽管特定菌株或克隆的传播可能也是一个因素。