乙酰胆碱对脑血管交感神经传递的调节作用。

Modulatory action of acetylcholine on cerebrovascular sympathetic neurotransmission.

Miranda F J, Torregrosa G, Salom J B, Alabadí J A, Alvarez C, Alborch E

Centro de Investigación, Hospital La Fe, Valencia, Spain.

Gen Pharmacol. 1991;22(6):1115-20. doi: 10.1016/0306-3623(91)90587-v.

Abstract

Acetylcholine (10 micrograms/min) diminished the electrically-induced cerebral blood flow reductions. Atropine (1-2 mg) partially blocked this inhibitory effect. 2. Exogenously administered noradrenaline (1-10 micrograms) and tyramine (50-500 micrograms) reduced cerebral blood flow but this effect was unchanged by acetylcholine infusion. 3. Acetylcholine inhibited the nonadrenergic component of the electrically-induced contraction at a concentration greater than or equal to 10(-6) M and potentiated the adrenergic component at a concentration greater than or equal to 10(5) M. Atropine 10(-7) M) inhibited both of these effects. In addition, acetylcholine (10(-4) M) enhanced the electrically-evoked [3H]noradrenaline overflow. 4. These results show that: (a) acetylcholine modulates cerebrovascular sympathetic neurotransmission by acting on muscarinic receptors; and (b) the potentiating effect of acetylcholine is achieved by a mechanism involving increases in noradrenaline release.

摘要

乙酰胆碱（10微克/分钟）可减轻电诱导的脑血流量减少。阿托品（1 - 2毫克）部分阻断了这种抑制作用。2. 外源性给予去甲肾上腺素（1 - 10微克）和酪胺（50 - 500微克）可减少脑血流量，但这种作用不受乙酰胆碱输注的影响。3. 乙酰胆碱在浓度大于或等于10⁻⁶ M时抑制电诱导收缩的非肾上腺素能成分，在浓度大于或等于10⁵ M时增强肾上腺素能成分。阿托品（10⁻⁷ M）抑制这两种作用。此外，乙酰胆碱（10⁻⁴ M）增强电诱发的[³H]去甲肾上腺素溢出。4. 这些结果表明：（a）乙酰胆碱通过作用于毒蕈碱受体调节脑血管交感神经传递；（b）乙酰胆碱的增强作用是通过涉及去甲肾上腺素释放增加的机制实现的。