Padberg B-C, Rordorf T, Suter S L, Pfeiffer D, Wild D, Schröder S
Institut für Klinische Pathologie, Universitätsspital, Schmelzbergstrasse 12, 8091, Zürich, Schweiz.
Pathologe. 2007 Jul;28(4):281-4. doi: 10.1007/s00292-006-0832-3.
(123)I-metaiodobenzylguanidine (MIBG), a radio-labeled catecholamine analogue, is used for the imaging of pheochromocytoma based on the selective uptake of MIBG by chromaffin tissues. MIBG scintigraphy displays high sensitivity (90%) and specificity (close to 100%). In contrast, the false-positive uptake of MIBG by adrenal cortical carcinoma is rare. Here, we report a metastatic oncocytic adrenal cortical carcinoma with MIBG uptake used for therapeutic purposes.
(123)间碘苄胍(MIBG)是一种放射性标记的儿茶酚胺类似物,基于嗜铬组织对MIBG的选择性摄取,它被用于嗜铬细胞瘤的成像。MIBG闪烁扫描显示出高灵敏度(90%)和特异性(接近100%)。相比之下,肾上腺皮质癌对MIBG的假阳性摄取很少见。在此,我们报告一例用于治疗目的的具有MIBG摄取的转移性嗜酸细胞性肾上腺皮质癌。