Dandri Maura, Lutgehetmann Marc, Volz Tassilo, Petersen Jörg
Department of Medicine, University Hospital Hamburg-Eppendorf, University of Hamburg, Germany.
Semin Liver Dis. 2006 May;26(2):181-91. doi: 10.1055/s-2006-939760.
The lack of reliable in vitro infection systems and convenient animal models has hindered progress in hepatitis B virus (HBV) research and the development of new treatment options. Due to various restraints encountered using chimpanzees and other models of HBV infection that are based on HBV-related viruses, and due to the necessity to work with small and well-characterized animal systems, it is not surprising that most recent developments have focused on mice. Various strains of transgenic mice harboring the entire HBV genome, or selected viral genes, were developed and proved to be very useful to elucidate mechanisms of HBV replication and pathogenesis. Furthermore, novel, exciting alternative mouse models have been developed recently, which allow not only studies on viral replication, but also the investigation of mechanisms of viral entry and clearance. This article provides an overview and discussion of the different mouse models of HBV replication and infection that are currently available.
缺乏可靠的体外感染系统和便捷的动物模型阻碍了乙型肝炎病毒（HBV）研究的进展以及新治疗方案的开发。由于使用黑猩猩和其他基于HBV相关病毒的HBV感染模型时遇到各种限制，并且由于需要使用小型且特征明确的动物系统，因此最近的进展大多集中在小鼠身上也就不足为奇了。各种携带完整HBV基因组或选定病毒基因的转基因小鼠品系被开发出来，并被证明对于阐明HBV复制和发病机制非常有用。此外，最近还开发了新颖且令人兴奋的替代小鼠模型，这些模型不仅可以用于研究病毒复制，还可以用于研究病毒进入和清除的机制。本文对目前可用的不同HBV复制和感染小鼠模型进行了概述和讨论。
