Orr-Urtreger A, Givol D, Yayon A, Yarden Y, Lonai P
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Development. 1991 Dec;113(4):1419-34. doi: 10.1242/dev.113.4.1419.
Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.
描述了两种密切相关的成纤维细胞生长因子受体bek和flg从植入后早期到晚期器官发生阶段的发育表达情况。bek和flg的转录本最初在卵柱期胚胎的原始外胚层中出现。随后，从体节发生开始，然后在整个胚胎发育过程中，它们在中胚层和神经外胚层中都被活跃转录。Bek也在表面外胚层和各种上皮中表达，而flg的表达主要局限于间充质。在肢芽中，bek转录本呈现出梯度样分布，并且比flg出现得更早。这两种受体，尽管它们的配体结合特异性几乎相同，但在整个发育过程中表现出不同的空间特异性，这表明发育定位可能有助于功能特异性。将讨论bek和flg在原肠胚形成以及器官发生的上皮-间充质相互作用中的作用。
