(IPr)Pd(acac)Cl：一种易于合成、高效且通用的用于C-N和C-C键形成的预催化剂。
(IPr)Pd(acac)Cl: an easily synthesized, efficient, and versatile precatalyst for C-N and C-C bond formation.
作者信息
Marion Nicolas, Ecarnot Elise C, Navarro Oscar, Amoroso Dino, Bell Andrew, Nolan Steven P
机构信息
Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
出版信息
J Org Chem. 2006 May 12;71(10):3816-21. doi: 10.1021/jo060190h.
A very straightforward synthesis of (IPr)Pd(acac)Cl from two commercially available starting materials, Pd(acac)2 and IPr.HCl [acac = acetylacetonate; IPr = N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene], has been developed. The resulting complex, (IPr)Pd(acac)Cl (1), has proven to be a highly active PdII precatalyst in the Buchwald-Hartwig and the alpha-ketone arylation reactions. A wide range of substrates has been screened, including unactivated, sterically hindered, and heterocyclic aryl chlorides.
已开发出一种非常直接的由两种市售起始原料Pd(acac)₂和IPr·HCl [acac = 乙酰丙酮; IPr = N,N'-双(2,6-二异丙基苯基)咪唑-2-亚基]合成(IPr)Pd(acac)Cl的方法。所得配合物(IPr)Pd(acac)Cl (1)已被证明是布赫瓦尔德-哈特维希反应和α-酮芳基化反应中一种高活性的PdII预催化剂。已筛选了多种底物，包括未活化的、空间位阻大的和杂环芳基氯化物。
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