DiMauro Erin F, Vitullo Jason R
Department of Chemistry Research and Discovery, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, USA.
J Org Chem. 2006 May 12;71(10):3959-62. doi: 10.1021/jo060218p.
The rapid and efficient synthesis of various disubstituted 5,6-fused heterocycles using a microwave-assisted one-pot cyclization-Suzuki coupling approach is described. This work highlights the tolerance of the boronic ester functional group to a variety of reaction conditions and the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse compound libraries.
描述了一种使用微波辅助一锅法环化-铃木偶联方法快速有效地合成各种二取代5,6-稠合杂环的方法。这项工作突出了硼酸酯官能团对各种反应条件的耐受性，以及官能化硼酸盐作为合成各种化合物库的倒数第二个中间体的实用性。
