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钯催化烯基铝与2-溴苯并呋喃的交叉偶联反应。

Palladium-catalyzed cross-coupling reaction of alkenyl aluminums with 2-bromobenzo[]furans.

作者信息

Wen Chang, Jiang Xin, Wu Kun, Luo Ruiqiang, Li Qinghan

机构信息

College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities Chengdu 610041 China

出版信息

RSC Adv. 2020 May 22;10(33):19610-19614. doi: 10.1039/d0ra02984j. eCollection 2020 May 20.

DOI:10.1039/d0ra02984j
PMID:35515440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9054126/
Abstract

Highly efficient and simple cross-coupling reactions of 2-bromobenzo[]furans with alkenylaluminum reagents for the synthesis of 2-alkenylbenzo[]furan derivatives using PdCl (3 mol%)/XantPhos (6 mol%) as catalyst are reported. Excellent yields (up to 97%) were obtained for a wide range of substrates at 80 °C for 4 h in DCE.

摘要

报道了使用PdCl（3摩尔%）/XantPhos（6摩尔%）作为催化剂，2-溴苯并呋喃与烯基铝试剂进行高效且简单的交叉偶联反应，用于合成2-烯基苯并呋喃衍生物。在80℃下于二氯乙烷中反应4小时，对于多种底物都获得了优异的产率（高达97%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/9054126/7420c16d32df/d0ra02984j-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/9054126/7420c16d32df/d0ra02984j-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3260/9054126/7420c16d32df/d0ra02984j-s3.jpg

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本文引用的文献

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