Liu Leifang, Zhang Yuhong, Xin Bingwei
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
J Org Chem. 2006 May 12;71(10):3994-7. doi: 10.1021/jo060122v.
A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction in aqueous phase was developed in short reaction times (0.5-1 h) at 35 degrees C in air. The key for such a successful catalytic system was the use of a suitable amount of cosolvents in the aqueous phase. The method could be extended to the consecutive multi-Suzuki coupling, and polyaryls were prepared in a single one-pot step in high selectivity and excellent yield under mild reaction conditions (60 degrees C).
在空气中35℃的条件下，开发了一种高效的醋酸钯催化的水相无配体铃木反应，反应时间短（0.5 - 1小时）。这种成功的催化体系的关键在于在水相中使用适量的助溶剂。该方法可扩展至连续多步铃木偶联反应，并且在温和的反应条件（60℃）下，通过单步一锅法以高选择性和优异产率制备多芳基化合物。
