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在水介质中通过醋酸钯催化的无配体铃木反应合成新型3,5-二氯-2-芳基吡啶

Synthesis of novel 3,5-dichloro-2-arylpyridines by palladium acetate-catalyzed ligand-free Suzuki reactions in aqueous media.

作者信息

Hu Huanan, Ge Changhua, Zhang Anjiang, Ding Lisheng

机构信息

College of Pharmaceutial and Chemical Engineering, Taizhou University, Linhai 317000, China.

出版信息

Molecules. 2009 Aug 26;14(9):3153-60. doi: 10.3390/molecules14093153.

DOI:10.3390/molecules14093153
PMID:19783914
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6254914/
Abstract

A highly efficient palladium acetate-catalyzed ligand-free Suzuki reaction of 2,3,5-trichloropyridine with arylboronic acids in aqueous phase was developed. High yields of 3,5-dichloro-2-arylpyridines, a simple Pd source, absence of ligands, and environmentally benign as well as mild reaction conditions are important features of this method.

摘要

开发了一种高效的醋酸钯催化的2,3,5-三氯吡啶与芳基硼酸在水相中的无配体铃木反应。该方法的重要特点是3,5-二氯-2-芳基吡啶产率高、钯源简单、无需配体以及反应条件对环境友好且温和。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce10/6254914/b5bf244a0358/molecules-14-03153-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce10/6254914/b5bf244a0358/molecules-14-03153-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce10/6254914/b5bf244a0358/molecules-14-03153-sch001.jpg

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本文引用的文献

1
A bowl-shaped phosphine as a ligand in palladium-catalyzed Suzuki-Miyaura coupling of aryl chlorides: effect of the depth of the bowl.一种碗状膦作为芳基氯钯催化铃木-宫浦偶联反应中的配体：碗深度的影响
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Synthesis of biaryls and polyaryls by ligand-free Suzuki reaction in aqueous phase.水相中无配体铃木反应合成联芳基和聚芳基化合物。
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Catalysts for Suzuki-Miyaura coupling processes: scope and studies of the effect of ligand structure.
新型 2-芳基苯并呋喃衍生物的钯催化Suzuki 交叉偶联反应在水相中的合成。
Molecules. 2018 Sep 25;23(10):2450. doi: 10.3390/molecules23102450.
4
Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes.杂芳基卤化物的位点选择性铃木-宫浦偶联反应——了解重要药物类别中的趋势
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Synthesis of (pyridin-2-yl)hydrazine conjugates as bifunctional chelates using the Suzuki-Miyaura reaction.使用铃木-宫浦反应合成作为双功能螯合剂的（吡啶-2-基）肼共轭物。
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Versatile synthesis of 3,5-disubstituted 2-fluoropyridines and 2-pyridones.3,5-二取代2-氟吡啶和2-吡啶酮的通用合成方法。
J Org Chem. 2003 Apr 18;68(8):3352-5. doi: 10.1021/jo026864f.
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Aryl-aryl bond formation one century after the discovery of the Ullmann reaction.乌尔曼反应发现一个世纪后的芳基-芳基键形成。
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