Hufford C D, Badria F A, Abou-Karam M, Shier W T, Rogers R D
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
J Nat Prod. 1991 Nov-Dec;54(6):1543-52. doi: 10.1021/np50078a008.
Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp. NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques. These metabolites have been identified as 18-hydroxystemodin [6], 16,18-dihydroxystemodin [7], 8 beta-hydroxystemodin [8], 8 beta, 18-dihydroxystemodin [9], and 7 beta, 8 beta-dihydroxystemodin [10]. The antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.
