一些新金刚烷类似物的合成、抗菌和抗病毒测试。
Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues.
机构信息
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
出版信息
Saudi Pharm J. 2010 Jul;18(3):123-8. doi: 10.1016/j.jsps.2010.05.004. Epub 2010 May 31.
Abstract
A new series of 1-adamantyl derivatives was designed, synthesized and evaluated for their antimicrobial and antiviral activities. Representative derivatives of the newly synthesized compounds were tested. Ampicillin, clotimazole and the antiviral antibiotic aphidicolin were used as positive controls. Compound 18 proved to be the most active member of this series as antimicrobial against Staphylococcus aureus and Candida albicans and as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.02 mg/ml while compound 19 proved to be the most active member of this series as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.01 mg/ml.
摘要
设计、合成了一系列新的 1-金刚烷基衍生物，并评价了它们的抗菌和抗病毒活性。对新合成化合物的代表性衍生物进行了测试。氨苄西林、克霉唑和抗病毒抗生素阿昔洛韦被用作阳性对照。化合物 18 是该系列中抗菌活性最强的成员，对金黄色葡萄球菌和白色念珠菌具有抗菌活性，抗病毒活性的 IC50 值为 0.21mg/ml，CD50 值为 0.02mg/ml；而化合物 19 是该系列中抗病毒活性最强的成员，抗病毒活性的 IC50 值为 0.21mg/ml，CD50 值为 0.01mg/ml。
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