Suzuki Toshihiro, Ikeda Hideyuki, Hamasaki Yoichiro, Hatamochi Atsushi, Yamazaki Soji
Department of Dermatology, Dokkyo University of School of Medicine, Mibu, Japan.
J Dermatol. 2006 Apr;33(4):249-51. doi: 10.1111/j.1346-8138.2006.00060.x.
A 65-year-old Japanese man presented with a gradually enlarging mass on the right side of the abdomen, which he had first noticed about 4 years previously. He was otherwise asymptomatic. Histopathological examination of the mass revealed an aggregation of neoplastic cells (tumor cell nests) with cellular proliferation extending from the epidermis to the dermis. The tumor consisted of two histologically distinct parts. One part was composed of uniformly small cells with a cuboidal appearance. Some ductal structures were visualized, and some of the cells lining the ductal lumina contained decapitation secretions. These histological changes were consistent with the diagnosis of apocrine poroma. The remaining part of the tumor was composed of cystic invaginations with numerous projections oriented toward the lumen. There were two rows of cells in the projections; the cells on the luminal side were columnar, and those at the apical aspect were small cuboidal cells. These histological changes were characteristic of syringocystadenoma papilliferum (SCAP). Based on these findings, a diagnosis of SCAP associated with apocrine poroma was made. To the best of our knowledge, there have been no previous reports of such a case in the published work.
一名65岁的日本男性患者，其腹部右侧有一个逐渐增大的肿块，他大约在4年前首次发现该肿块。除此之外，他没有其他症状。对该肿块进行组织病理学检查发现，肿瘤细胞聚集（肿瘤细胞巢），细胞增殖从表皮延伸至真皮。肿瘤由两个组织学上不同的部分组成。一部分由外观呈立方形的均匀小细胞组成。可见一些导管结构，一些导管腔内衬的细胞含有断头分泌。这些组织学变化符合大汗腺汗孔瘤的诊断。肿瘤的其余部分由囊性内陷组成，有许多朝向管腔的突起。突起中有两排细胞；管腔侧的细胞为柱状，顶端的细胞为小立方形细胞。这些组织学变化是乳头状汗腺囊腺瘤（SCAP）的特征。基于这些发现，诊断为与大汗腺汗孔瘤相关的SCAP。据我们所知，此前在已发表的文献中尚无此类病例的报道。
