Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Neurobiol Dis. 2013 Apr;52:4-11. doi: 10.1016/j.nbd.2012.01.015. Epub 2012 Feb 10.
Recent research detailing the intrinsic functional organization of the brain provides a unique and useful framework to gain a better understanding of the neural bases of Major Depressive Disorder (MDD). In this review, we first present a brief history of neuroimaging research that has increased our understanding of the functional macro-architecture of the brain. From this macro-architectural perspective, we examine the extant body of functional neuroimaging research assessing MDD with a specific emphasis on the contributions of default-mode, executive, and salience networks in this debilitating disorder. Next, we describe recent investigations conducted in our laboratory in which we explicitly adopt a neural-system perspective in examining the relations among these networks in MDD. Finally, we offer directions for future research that we believe will facilitate the development of more detailed and integrative models of neural dysfunction in depression.
最近详细描述大脑内在功能组织的研究为更好地理解重度抑郁症（MDD）的神经基础提供了一个独特而有用的框架。在这篇综述中，我们首先介绍了神经影像学研究的简要历史，这些研究增进了我们对大脑功能宏观结构的理解。从这个宏观结构的角度来看，我们检查了评估 MDD 的功能神经影像学研究的现有文献，特别强调了默认模式、执行和突显网络在这种使人衰弱的疾病中的作用。接下来，我们描述了我们实验室最近进行的研究，我们在这些研究中明确采用了神经系统的观点来检查 MDD 中这些网络之间的关系。最后，我们为未来的研究提供了方向，我们相信这将有助于开发更详细和综合的抑郁神经功能障碍模型。
