荷兰阿姆斯特丹针对流动儿童的甲型肝炎疫苗接种计划的成效（1992 - 2004年）

Effectiveness of a hepatitis A vaccination program for migrant children in Amsterdam, The Netherlands (1992-2004).

作者信息

Sonder G J B, Bovée L P M J, Baayen T D, Coutinho R A, van den Hoek J A R

机构信息

GGD, Municipal Health Service Amsterdam, Department of Infectious Diseases, Nieuwe Achtergracht 100, PO Box 2200, 1000 CE Amsterdam, The Netherlands.

出版信息

Vaccine. 2006 Jun 5;24(23):4962-8. doi: 10.1016/j.vaccine.2006.03.075. Epub 2006 Apr 18.

DOI:10.1016/j.vaccine.2006.03.075

PMID:16675076

Abstract

OBJECTIVE

To evaluate the impact and effectiveness of risk-group vaccination against hepatitis A targeted at migrant children living in a country with low endemicity of hepatitis A.

METHODS

Retrospective population based data analysis. Routinely collected data on hepatitis A incidence in migrant children and other risk groups in Amsterdam from 1 January 1992 to 2004 were analyzed and related to exposure, immunity and vaccination coverage in migrant children.

RESULTS

The overall hepatitis A incidence in Amsterdam declined after a pediatric vaccine was introduced in 1997. This decline was seen in migrant children traveling to hepatitis A-endemic countries, contacts with hepatitis A patients, primary school students, injecting drug users, and persons with unknown source of infection, but not in men who have sex with men (MSM) or in travelers to endemic countries other than migrant children.

CONCLUSION

The hepatitis A vaccination campaigns are effective: they reduce both import and secondary HAV cases. The campaigns could be more efficient and cost-effective if the hepatitis B vaccinations currently given to these groups were replaced by a combined hepatitis A and B vaccine. This would increase the hepatitis A vaccination coverage considerably and further reduce the hepatitis A incidence.

摘要