Hardie Thomas L, Moss Howard B, Lynch Kevin G
University of Delaware, Department of Nursing, Rm 361 McDowell Hall, Newark, DE 19716, USA.
Addict Behav. 2006 Nov;31(11):2030-7. doi: 10.1016/j.addbeh.2006.02.010. Epub 2006 May 3.
Early exposure to cigarettes is connected to increasing rate of regular use later in life. We examine genetic correlation between the age of first cigarette and later smoking related behaviors. The sample consisted of twin ages 25 to 75. Biometrical analysis was used to evaluate the heritabilities and a second analyses based on Cholesky decomposition determined the shared variance. The genetic variance ranged from 48% to 69%. Models comparing age of first cigarette to and smoking persistence, cessation, and number of cigarettes during year smoked most individually indicated a very small proportion of shared genetic variance (ranging from 0.004 to 0.056). These findings support separate genetic and unshared environmental processes for the age of first cigarette as compared to three other smoking related phenotypes. Research in substance abuse risk and prevention literature suggests that delaying initial exposure is a critical step reducing in the risk of later regular use. The interventional implications of the findings support the importance of a tailored approach to preventing smoking behavior and reducing harm in smokers.
早期接触香烟与日后生活中经常吸烟的比率增加有关。我们研究首次吸烟年龄与日后吸烟相关行为之间的遗传相关性。样本包括年龄在25岁至75岁之间的双胞胎。采用生物统计学分析来评估遗传力，并基于乔列斯基分解进行的二次分析确定共享方差。遗传方差范围为48%至69%。将首次吸烟年龄与吸烟持续性、戒烟情况以及每年吸烟量进行比较的模型，单独来看，大多数情况下显示共享遗传方差的比例非常小（范围从0.004到0.056）。这些发现支持了与其他三种吸烟相关表型相比，首次吸烟年龄存在独立的遗传和非共享环境过程。药物滥用风险与预防文献中的研究表明，延迟首次接触是降低日后经常使用风险的关键步骤。这些发现的干预意义支持了采用量身定制的方法来预防吸烟行为和减少吸烟者危害的重要性。
