Bubak-Satora M, Skowron-Cendrzak A, Kubera M
Department of Immunobiology, Polish Academy of Sciences, Kraków.
Folia Biol (Krakow). 1991;39(1-4):21-4.
The immunomodulatory effect of lithium chloride (LiCl) administered i.p. to adult mice (150 mg/kg/day) on cellular immunity in vivo was investigated. A short (6-day) treatment with LiCl of either spleen cell donors in semiallogeneic or xenogeneic GVH reaction, or recipients in semiallogeneic HVG reaction, significantly diminished the early sings of local cell-mediated immunity. A short-term LiCl treatment of donor mice also abrogated systemic GVH reaction in newborn F1 recipients, while a treatment prolonged for 20 days did not alter the high GVH response of spleen cells typical for untreated donors. Thus, a striking time-dependent efficacy of LiCl on the reduction of GVH reaction was found.
研究了腹腔注射氯化锂（LiCl，150mg/kg/天）对成年小鼠体内细胞免疫的免疫调节作用。在半同种异体或异种移植物抗宿主（GVH）反应中，对脾细胞供体进行为期6天的LiCl短期处理，或在半同种异体宿主抗移植物（HVG）反应中对受体进行短期处理，均显著减弱了局部细胞介导免疫的早期迹象。对供体小鼠进行短期LiCl处理也消除了新生F1受体中的全身性GVH反应，而延长至20天的处理并未改变未处理供体典型的脾细胞高GVH反应。因此，发现LiCl对降低GVH反应具有显著的时间依赖性疗效。
