Ruffato Alberto, Mattioli Sandro, Lugaresi Maria Luisa, D'Ovidio Franco, Antonacci Filippo, Di Simone Massimo Pierluigi
Division of Oesophageal and Pulmonary Surgery, Villa Maria Cecilia and San Pier Damiano Hospitals, Cotignola and Faenza, Ravenna, Italy.
Eur J Cardiothorac Surg. 2006 Jun;29(6):914-9. doi: 10.1016/j.ejcts.2006.03.044. Epub 2006 May 3.
In the literature, reports on the definitive rate of cure of the surgical treatment of oesophageal achalasia are not numerous. The aim of this study is to assess the clinical-instrumental-based patient's outcome related to long-term follow-up.
One hundred and seventy-four patients (80 men, median age 57 years, range 7-83) consecutively submitted to first instance transabdominal Heller-Dor in the period 1978-2002 were considered. Follow-up consisted of clinical interview, endoscopy, barium-swallow and oesophageal manometry if required. Twenty-six cases (15%) were sigmoid achalasias.
One patient died post-operatively (severe haemorrhage in a patient previously operated upon for a cardiovascular malformation and suffering for portal hypertension), 173 were followed-up (mean 109 months, range 12-288, median 93 months) of whom 68 for more than 15 years. On the whole 151 patients (87.3%) had satisfactory and 22 (12.7%) had poor long-term results. Seven out of 173 patients (4%), 6 of whom were pre-operatively classified as sigmoid achalasia, subsequently underwent oesophagectomy, 3 for epidermoid cancer, 1 for Barrett's adenocarcinoma, 2 for stasis oesophagitis and recurrent sepsis, 1 for severe dysphagia. Fifteen patients (8.7%) had an insufficient result due to reflux oesophagitis which appeared in 2 (one erosion) after 184 and 252 months. All 22 patients, whether surgically or medically retreated, achieved satisfactory control of dysphagia and reflux symptoms.
In the long term, insufficient results strictly related to Heller-Dor failure, always due to reflux oesophagitis, were recorded in 15/173 patients (8.7%) although it is questionable whether reflux oesophagitis appearing after more than 15 years is due to the Dor incompetence or to ageing. In sigmoid achalasia, oesophagectomy rather than myotomy should be taken into consideration in the first instance. In the long-term, surgery is the best definitive treatment for oesophageal achalasia.
在文献中,关于食管贲门失弛缓症手术治疗的确切治愈率报告并不多。本研究的目的是评估基于临床检查的患者长期随访结果。
研究对象为1978年至2002年间连续接受首例经腹Heller-Dor手术的174例患者(80例男性,中位年龄57岁,年龄范围7 - 83岁)。随访包括临床访谈、内镜检查、吞钡检查以及必要时的食管测压。其中26例(15%)为乙状结肠型贲门失弛缓症。
1例患者术后死亡(1例曾因心血管畸形接受手术且患有门静脉高压症的患者出现严重出血),173例患者接受了随访(平均随访109个月,范围12 - 288个月,中位随访时间93个月),其中68例患者的随访时间超过15年。总体而言,151例患者(87.3%)的长期效果令人满意,22例患者(12.7%)效果不佳。173例患者中有7例(4%)随后接受了食管切除术,其中6例术前被归类为乙状结肠型贲门失弛缓症,3例因鳞状细胞癌接受手术,1例因巴雷特腺癌接受手术,2例因淤滞性食管炎和反复感染接受手术,1例因严重吞咽困难接受手术。15例患者(8.7%)因反流性食管炎导致手术效果不佳,反流性食管炎分别在术后184个月和252个月出现2例(其中1例出现糜烂)。所有22例患者,无论接受手术治疗还是药物治疗,吞咽困难和反流症状均得到了满意控制。
从长期来看,173例患者中有15例(8.7%)出现了与Heller-Dor手术失败密切相关的不理想结果,且均由反流性食管炎引起,不过,15年后出现的反流性食管炎是由于Dor瓣功能不全还是衰老所致仍存在疑问。对于乙状结肠型贲门失弛缓症,首先应考虑食管切除术而非肌切开术。从长期来看,手术是治疗食管贲门失弛缓症的最佳确定性治疗方法。