Zablotsky M, Meffert R, Caudill R, Evans G
Division of Periodontology, University of California, San Francisco.
Int J Oral Maxillofac Implants. 1991 Fall;6(3):294-303.
Fifty-six endosseous cylindrical implants were placed in dog mandibles 12 weeks after the extraction of all mandibular premolars and first molars. Eight implants, four coated with 50 microns of hydroxylapatite (HA) and four grit-blasted and titanium-surfaced, were placed in each dog. Ideal implant placement sites were modified by creating standardized 3 x 5-mm facial dehiscence defects. Half the dehiscences were treated with a modified expanded polytetrafluoroethylene (PTFE) membrane; the remainder served as controls. After 8 weeks of healing, the animals were sacrificed and measurements made to determine the percentage of dehiscence repair. The HA-coated implants had a mean defect fill of 95.17% and the grit-blasted implants had a percent fill of 82.8% in the guided tissue regeneration (GTR) test group; the control implants demonstrated a mean fill of 55% and 39% in the HA-coated and grit-blasted implants, respectively. Significant differences (P less than .05) were noted between both test groups and the titanium control group, and between the HA test and HA control groups. Histologic evaluation showed significantly greater repair associated with HA-coated implants, as well as significant bone loss associated with clinically exposed membranes. It was concluded that within the limitations of this study, guided tissue regeneration is a viable option in treating defects associated with dental implants.
在拔除所有下颌前磨牙和第一磨牙12周后，将56枚骨内圆柱形种植体植入犬下颌骨。每只犬植入8枚种植体，其中4枚涂有50微米的羟基磷灰石（HA），4枚经喷砂处理并带有钛表面。通过制造标准化的3×5毫米面部裂开缺损来改变理想的种植体植入部位。一半的裂开部位用改良的膨体聚四氟乙烯（PTFE）膜治疗；其余作为对照。愈合8周后，处死动物并进行测量以确定裂开修复的百分比。在引导组织再生（GTR）试验组中，HA涂层种植体的平均缺损填充率为95.17%，喷砂处理的种植体填充率为82.8%；对照种植体在HA涂层和喷砂处理的种植体中的平均填充率分别为55%和39%。在两个试验组与钛对照组之间，以及HA试验组与HA对照组之间均观察到显著差异（P小于0.05）。组织学评估显示，与HA涂层种植体相关的修复明显更多，并且与临床暴露的膜相关的骨丢失也很明显。得出的结论是，在本研究的局限性范围内，引导组织再生是治疗与牙种植体相关缺损的一种可行选择。
