Panos Aristotelis, Murith Nicolas, Bednarkiewicz Marek, Khatchatourov Gregory
Clinic for Cardiac Surgery, University Hospital of Geneva, Geneva, Switzerland.
Eur J Cardiothorac Surg. 2006 Jun;29(6):1036-9. doi: 10.1016/j.ejcts.2006.03.032. Epub 2006 May 3.
Aortic arch surgery is still associated with increased mortality and morbidity especially in acute type A aortic dissection. Adequate brain protection is essential and commonly performed by either antegrade selective perfusion of the brachiocephalic arteries or an interval of profound hypothermic circulatory arrest. We present our experience for open aortic arch repair with continuous antegrade brain perfusion by means of direct cannulation of the right axillary artery, under moderate hypothermia in patients with acute type A aortic dissection.
In, 25 consecutive patients (17 men) with a mean age of 62.6+/-14.8 years, aortic repair extended to the arch, for acute type A aortic dissection, was performed through a midline sternotomy. The right axillary artery was used for arterial systemic and brain perfusion at a rectal temperature of 25-27 degrees C.
Mean duration of CPB and aortic cross-clamping was 241+/-55 and 155+/-72 min, respectively. The mean duration of circulatory arrest of the lower body and brain perfusion was 39.7 (range, 24-55 min). All the patients survived the procedure and all but one were discharged from hospital. One patient had left arm paralysis which he recovered the first postoperative month. There were no other transient or permanent neurologic deficits. A CT scan was performed at discharge for routine postoperative evaluation. There were no local neurovascular complications related to the cannulation site except for one local re-exploration for bleeding.
The absence of any major permanent neurologic deficit or any visceral damages in our patients suggests that continuous moderate hypothermic cerebral perfusion, with an interval of circulatory arrest of the lower body, is adequate for acute type A aortic dissection surgery, allowing safe open repair of the distal aortic arch.
主动脉弓手术仍然与死亡率和发病率的增加相关,尤其是在急性A型主动脉夹层中。充分的脑保护至关重要,通常通过头臂动脉的顺行选择性灌注或一段深度低温循环停止来实现。我们介绍了在急性A型主动脉夹层患者中,在中度低温下通过直接插管右腋动脉进行持续顺行脑灌注的开放性主动脉弓修复经验。
连续25例患者(17例男性),平均年龄62.6±14.8岁,因急性A型主动脉夹层行主动脉修复并延伸至主动脉弓,通过正中胸骨切开术进行。在直肠温度为25 - 27摄氏度时,使用右腋动脉进行动脉系统和脑灌注。
体外循环和主动脉阻断的平均持续时间分别为241±55分钟和155±72分钟。下半身循环停止和脑灌注的平均持续时间为39.7分钟(范围24 - 55分钟)。所有患者均手术存活,除1例患者外均出院。1例患者出现左臂麻痹,在术后第一个月恢复。无其他短暂或永久性神经功能缺损。出院时进行CT扫描用于常规术后评估。除1例因出血进行局部再次探查外,未发现与插管部位相关的局部神经血管并发症。
我们的患者中未出现任何重大永久性神经功能缺损或任何内脏损伤,这表明持续中度低温脑灌注,结合下半身循环停止的间隔,对于急性A型主动脉夹层手术是足够的,允许安全地开放性修复主动脉弓远端。