Boyes Richard G, Rueckert Daniel, Aljabar Paul, Whitwell Jennifer, Schott Jonathan M, Hill Derek L G, Fox Nicholas C
Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London WC1N 3BG, UK.
Neuroimage. 2006 Aug 1;32(1):159-69. doi: 10.1016/j.neuroimage.2006.02.052. Epub 2006 May 3.
We compared two methods of measuring cerebral atrophy in a cohort of 38 clinically probable Alzheimer's disease (AD) subjects and 22 age-matched normal controls, using metrics of zero atrophy, consistency, scaled atrophy and AD/control group separation. The two methods compared were the boundary shift integral (BSI) and a technique based on the integration of Jacobian determinants from non-rigid registration. For each subject, we used two volumetric magnetic resonance (MR) scans at baseline and a third obtained 1 year later. The case of zero atrophy was established by registering the same-day baseline scan pair, which should approximate zero change. Consistency was established by registering the 1-year follow-up scan to each of the baseline scans, giving two measurements of atrophy that should be very similar, while scaled atrophy was established by reducing one of the same-day scans by a fixed amount, and rigidly registering this to the other same-day scan. Group separation was ascertained by calculating atrophy rates over the two 1-year measures for the control and AD subjects. The results showed the Jacobian integration technique was significantly more accurate in calculating scaled atrophy (P < 0.001) and was able to distinguish between control and AD subjects more clearly (P < 0.01).
我们在一个由38名临床诊断为可能患有阿尔茨海默病（AD）的受试者和22名年龄匹配的正常对照组成的队列中，使用零萎缩、一致性、缩放萎缩和AD/对照组分离等指标，比较了两种测量脑萎缩的方法。所比较的两种方法分别是边界位移积分（BSI）和一种基于非刚性配准的雅可比行列式积分的技术。对于每个受试者，我们在基线时使用了两次容积磁共振（MR）扫描，并在1年后获得了第三次扫描。通过配准同一天的基线扫描对来确定零萎缩的情况，这应该接近零变化。通过将1年随访扫描与每次基线扫描进行配准来确定一致性，从而给出两个应该非常相似的萎缩测量值，而缩放萎缩是通过将同一天的一次扫描减少固定量，并将其刚性配准到另一次同一天扫描来确定的。通过计算对照组和AD组受试者在两个1年测量期内的萎缩率来确定组间分离。结果表明，雅可比积分技术在计算缩放萎缩方面显著更准确（P < 0.001），并且能够更清晰地区分对照组和AD组受试者（P < 0.01）。
