Moore Martin L, Peebles R Stokes
Division of Allergy, Pulmonary, and Critical Care Medicine, Center for Lung Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
J Allergy Clin Immunol. 2006 May;117(5):1036-9. doi: 10.1016/j.jaci.2005.12.1314. Epub 2006 Feb 15.
Prostaglandins (PGs), small lipid molecules derived from arachidonic acid by COX enzymes, are critical mediators of allergic inflammation. Our understanding of the role of PGs in allergic lung inflammation has been hampered by the very short biologic half-life of these mediators, which has made mechanistic studies difficult in human subjects. However, advances in molecular biology and pharmacology have given investigators the opportunity to examine the role of specific prostanoids in the development of allergic inflammation in animal models. Studies investigating specific PG receptors are also elucidating the mechanisms by which PGs regulate the pulmonary allergic phenotype. This review summarizes the current literature on the role of PGs and PG receptors in allergic lung inflammation.
前列腺素（PGs）是由COX酶从花生四烯酸衍生而来的小分子脂质，是过敏性炎症的关键介质。这些介质极短的生物半衰期阻碍了我们对PGs在过敏性肺部炎症中作用的理解，这使得在人类受试者中进行机制研究变得困难。然而，分子生物学和药理学的进展使研究人员有机会在动物模型中研究特定前列腺素在过敏性炎症发展中的作用。对特定PG受体的研究也在阐明PGs调节肺部过敏表型的机制。这篇综述总结了关于PGs和PG受体在过敏性肺部炎症中作用的当前文献。
