Lavretsky Helen, Nguyen Lang Hai
University of California, Los Angeles, CA 90095, USA.
Psychiatr Serv. 2006 May;57(5):617-9. doi: 10.1176/ps.2006.57.5.617.
The authors review research on the treatment of behavioral disturbances and psychiatric symptoms of patients with dementia, including pharmacological treatment with antipsychotics, antidepressants, cholinesterase inhibitors, and other psychotropic drugs. They conclude that although these medications have some beneficial effects, no intervention is currently able to eradicate behavioral disturbances and psychiatric symptoms of demented patients. Research suggests that multiple interventions for an individual patient are likely to replace the use of a single treatment. Such interventions include caregiver training and support, antipsychotics, antidepressants, and cholinesterase inhibitors, along with other drugs developed for the treatment of Alzheimer's disease.
作者回顾了关于痴呆症患者行为障碍和精神症状治疗的研究，包括使用抗精神病药物、抗抑郁药物、胆碱酯酶抑制剂和其他精神药物进行药物治疗。他们得出结论，尽管这些药物有一些有益效果，但目前没有干预措施能够根除痴呆症患者的行为障碍和精神症状。研究表明，针对个体患者的多种干预措施可能会取代单一治疗的使用。这些干预措施包括照顾者培训与支持、抗精神病药物、抗抑郁药物、胆碱酯酶抑制剂，以及其他为治疗阿尔茨海默病而研发的药物。
