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老年精神科住院病房中痴呆行为和心理症状的药物治疗

Pharmacological treatment of behavioural and psychological symptoms of dementia in psychogeriatric inpatient units.

作者信息

Restifo Sam, Lemon Vivienne, Waters Flavie

机构信息

North Metropolitan Area Older Adult Mental Health Service, Perth, WA, Australia.

出版信息

Australas Psychiatry. 2011 Feb;19(1):59-63. doi: 10.3109/10398562.2010.539611. Epub 2010 Dec 29.

Abstract

OBJECTIVE

This study involved an examination of the current patterns of pharmacological treatment of patients with behavioural and psychological symptoms of dementia (BPSD) in psychogeriatric inpatient units.

METHOD

An audit was conducted of discharge medications of patients with BPSD who were hospitalized at three separate inpatient units in Perth, Western Australia over a 1-year period.

RESULTS

Prescribing patterns were found to be relatively similar across the three units. Dementia-specific drugs such as choline-esterase inhibitors and memantine comprised a minority of prescribed medication. Antipsychotics, benzodiazepines and sodium valproate were the most commonly prescribed drugs. Cyproterone acetate was used in a small number of patients at each of the three units.

CONCLUSIONS

The broad range of medications used to treat BPSD, the relatively modest place of dementia-specific drugs in this patient group, and the co-prescribing of more than one psychotropic agent in the majority of patients support the prevailing impressions that BPSD are difficult to treat and that there is no consistently effective or superior medication or drug group.

摘要

目的

本研究对老年精神科住院病房中痴呆患者行为和心理症状(BPSD)的当前药物治疗模式进行了调查。

方法

对西澳大利亚州珀斯三个独立住院病房中住院的BPSD患者在1年期间的出院用药情况进行了审核。

结果

发现三个病房的处方模式相对相似。胆碱酯酶抑制剂和美金刚等痴呆特异性药物在处方药物中占少数。抗精神病药、苯二氮䓬类药物和丙戊酸钠是最常用的药物。三个病房均有少数患者使用醋酸环丙孕酮。

结论

用于治疗BPSD的药物种类繁多,痴呆特异性药物在该患者群体中的地位相对不突出,且大多数患者同时使用多种精神药物,这些都支持了普遍的观点,即BPSD难以治疗,且没有始终有效或更优的药物或药物类别。

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