Ragsdale C W, Brockes J P
Ludwig Institute for Cancer Research, Middlesex Hospital, London, UK.
Curr Opin Cell Biol. 1991 Dec;3(6):928-34. doi: 10.1016/0955-0674(91)90109-c.
The elaboration of the effect of retinoic acid on limb morphogenesis has prompted renewed investigation into the teratology of retinoic acid treatment, with the hope that such analysis might give insight into mechanisms of vertebrate patterning. Retinoids, their nuclear receptors and their cytoplasmic binding proteins are now known to be deployed throughout development, but the extent to which they are natural agents of morphogenesis remains obscure. The study of retinoic acid receptors may offer molecular insight into gene regulation underlying vertebrate pattern formation.
视黄酸对肢体形态发生作用的阐述促使人们重新研究视黄酸治疗的致畸学，希望这种分析能深入了解脊椎动物模式形成的机制。现在已知类视黄醇、它们的核受体及其细胞质结合蛋白在整个发育过程中都有分布，但它们作为形态发生天然因子的程度仍不清楚。对视黄酸受体的研究可能为脊椎动物模式形成背后的基因调控提供分子层面的见解。
