Tsonis Panagiotis A, Washabaugh Charles H, Del Rio-Tsonis Katia
Laboratory of Molecular Biology, Department of Biology, University of Dayton, 45469-2320, Dayton, OH, USA.
Rouxs Arch Dev Biol. 1994 Jan;203(4):230-234. doi: 10.1007/BF00636339.
9-cis-retinoic acid has recently been found to be a high affinity ligand for the retinoic X receptor (RXR). RXRs are believed to be involved in metabolic activities rather than in morphogenetic ones. Interestingly, RXR has been found to form heterodimers involving other receptors from the steroid family, such as the thyroid hormone receptor, vitamin D receptor or retinoic acid receptors (RARs). In this paper we examined whether or not 9-cis-retinoic acid had any morphogenetic properties on the regenerating axolotl limb. It is shown that 9-cis-retinoic acid proximalized regenerating limbs and was somewhat more potent in this action than all-trans-retinoic acid. Based on these observations, the possible roles of other receptors during pattern formation is discussed.
9-顺式视黄酸最近被发现是视黄酸X受体（RXR）的高亲和力配体。人们认为RXR参与代谢活动而非形态发生活动。有趣的是，已发现RXR能与类固醇家族的其他受体形成异源二聚体，如甲状腺激素受体、维生素D受体或视黄酸受体（RAR）。在本文中，我们研究了9-顺式视黄酸对蝾螈再生肢体是否具有任何形态发生特性。结果表明，9-顺式视黄酸使再生肢体向近端化，并且在这一作用中比全反式视黄酸稍强。基于这些观察结果，讨论了其他受体在模式形成过程中的可能作用。
